Journal
JOURNAL OF NEUROSCIENCE
Volume 21, Issue 10, Pages 3697-3703Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.21-10-03697.2001
Keywords
long-term potentiation; reinforcement; heterosynaptic LTP; associative LTP; late-LTP; basolateral amygdala; hippocampus; dentate gyrus
Categories
Ask authors/readers for more resources
The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long- term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early- LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early- LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and beta- adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available