Journal
JOURNAL OF NEUROSCIENCE
Volume 21, Issue 10, Pages 3600-3608Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.21-10-03600.2001
Keywords
macaque; visual cortex; V1; layer 6; photostimulation; excitatory input; local circuits; caged glutamate
Categories
Funding
- NEI NIH HHS [R01 EY010742, EY10742] Funding Source: Medline
- NIGMS NIH HHS [T32 GM08107-15, T32 GM008107] Funding Source: Medline
Ask authors/readers for more resources
Layer 6 of monkey V1 contains a physiologically and anatomically diverse population of excitatory pyramidal neurons. Distinctive arborization patterns of axons and dendrites within the functionally specialized cortical layers define eight types of layer 6 pyramidal neurons and suggest unique information processing roles for each cell type. To address how input sources contribute to cellular function, we examined the laminar sources of functional excitatory input onto individual layer 6 pyramidal neurons using scanning laser photostimulation. We find that excitatory input sources correlate with cell type. Class I neurons with axonal arbors selectively targeting magnocellular (M) recipient layer 4C alpha receive input from M- dominated layer 4B, whereas class I neurons whose axonal arbors target parvocellular (P) recipient layer 4C beta receive input from P- dominated layer 2/ 3. Surprisingly, these neuronal types do not differ significantly in the inputs they receive directly from layers 4C alpha or 4C beta. Class II cells, which lack dense axonal arbors within layer 4C, receive excitatory input from layers targeted by their local axons. Specifically, type IIA cells project axons to and receive input from the deep but not superficial layers. Type IIB neurons project to and receive input from the deepest and most superficial, but not middle layers. Type IIC neurons arborize throughout the cortical layers and tend to receive inputs from all cortical layers. These observations have implications for the functional roles of different layer 6 cell types in visual information processing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available