Journal
ORGANIC LETTERS
Volume 3, Issue 10, Pages 1543-1545Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol015845+
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[GRAPHICS] The novel alkaloids 1 and 4 were isolated from an Australian non-verongid sponge, Oceanapia sp, Compound 1 contains an unprecedented imidazolyl-quinolinone substructure attached to a bromotyrosine-derived spiro isoxazoline. Three other known alkaloids were isolated in addition to 1 and 4 and together represent the first examples of inhibitors of a new mycobacterial enzyme mycothiol S-conjugate amidase (MCA).
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