Journal
ANALYTICA CHIMICA ACTA
Volume 435, Issue 1, Pages 115-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0003-2670(01)00913-8
Keywords
Troger's base; polymers; solid-phase extraction
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Molecularly imprinted polymers (MIPs) selective for Troger's base were designed and synthesised, and HPLC-chromatographic evaluation of polymer recognition characteristics was undertaken. Baseline separation of racemic Troger's base was readily achieved, and enantioseparation factors (alpha) of up to 4.8 +/- 0.2 were obtained. The high enantioselectivity demonstrated by these materials prompted their use to examine the kinetics and thermodynamics of individual enantiomers in a solid-phase extraction (SPE) process. Enantiomer-dependent differences in the rates and extent of adsorption were observed. Furthermore, the enantiomeric enrichment of racemates was demonstrated in batch studies. (C) 2001 Elsevier Science B.V. All rights reserved.
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