Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 11, Issue 10, Pages 1269-1272Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00198-6
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- NCI NIH HHS [CA 74708] Funding Source: Medline
- NIGMS NIH HHS [GM 60642] Funding Source: Medline
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Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactase moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase. (C) 2001 Elsevier Science Ltd. All rights reserved.
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