Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins

The stereoselective synthesis of 2,6-dimethyl-1,5-diaza-cis-decalins with the dimethyl groups syn or anti to the angular hydrogens has been accomplished starting from 1,5-diaza-cis-decalin. From an NMR study of the conformational properties of all three 2,6-dimethyl-1,5-diaza-cis-decalins, the components which affect the conformational equilibrium have been identified. (C) 2001 Elsevier Science Ltd. All rights reserved.