Journal
VETERINARY MICROBIOLOGY
Volume 80, Issue 2, Pages 101-119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1135(00)00388-6
Keywords
classical swine fever virus; pig virus; gp55; E2; DNA vaccination; recombinant adenovirus; protection
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Weaned pigs (6-week-old) and 7-day-old pre-weaned piglets were vaccinated with naked plasmid DNA expressing the gp55/E2 gene from classical swine fever virus (CSFV). Both groups of pigs were then given a booster dose of recombinant porcine adenovirus expressing the gp55 gene (rPAV-gp55). Following challenge with CSFV: 100% of weaned pigs and 75% pre-weaned piglets were protected from disease. Weaned pigs given a single dose of rPAV-gp55 were also protected, but showed a slight increase in temperature immediately post-challenge. However. weaned animals given a DNA prime before rPAV-gp55 showed no fluctuation in body temperature following challenge and no pathology in spleen or lymph nodes upon post-mortem, In addition, no CSFV could be re-isolated from the rPAV vaccinated group and from only one pig in the prime-boost group following challenge, suggesting that both vaccination regimes have the potential to reduce or prevent virus shedding following experimental. challenge. (C) 2001 Elsevier Science B.V. All rights reserved.
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