Journal
NEUROLOGY
Volume 56, Issue 10, Pages 1399-1402Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.56.10.1399
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An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.
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