Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 918, Issue 2, Pages 435-438Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(01)00779-8
Keywords
food analysis; dimetridazole; ronidazole; metronidazole
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A method was developed for the determination of the nitroimidazole compounds dimetridazole (DMZ), ronidazole (RNZ) and metronidazole (MNZ) by gas chromatography with nitrogen phosphorus detection. Nitroimidazole compounds were extracted with acetonitrile, followed by acidification using acetic acid and cleanup using strong cation-exchange (SCX) SPE column. Validation in chicken muscle fortified at a concentration of 5 mug/kg gave mean recoveries of 85% DMZ, 90% RNZ, 80% MNZ with RSDs of 13.0, 14.3, 11.2%, respectively (n=6). The method is suitable for statutory residue testing and is used as a quick screening method in the National Residue Surveillance Plan in China. (C) 2001 Elsevier Science B.V. All rights reserved.
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