Journal
JOURNAL OF CHROMATOGRAPHY B
Volume 756, Issue 1-2, Pages 189-198Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-4347(01)00108-6
Keywords
food allergy; ovalbumin
Funding
- NHLBI NIH HHS [F32 HL09927-01] Funding Source: Medline
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Ovalbumin is a protein of unknown function found in large quantities in avian egg-white. Surprisingly, ovalbumin belongs to the serpin family although it lacks any protease inhibitory activity. We review here what is known about the amino acid sequence, post-translational modifications and tertiary structure of ovalbumin. The properties of ovalbumin are discussed in relation to their possible functional significance. These include reasons for failure of ovalbumin to undergo a typical serpin conformational change involving the reactive centre loop, which explains why ovalbumin is not a protease inhibitor, and also the natural conversion of ovalbumin to the more stable S form. (C) 2001 Elsevier Science B.V. All rights reserved.
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