Journal
NEUROREPORT
Volume 12, Issue 7, Pages 1351-1354Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200105250-00012
Keywords
acetylcholine; di-hydro-beta-erythroidine; GABAergic transmission; hippocampus; inhibitory transmission; IPSC; methyllicaconitine; nicotinic receptors; spontaneous activity
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Nicotine modulates excitatory and inhibitory transmission in the hippocampus by acting on receptors located on various cellular compartments. We report that nicotine, applied for 5-10 min at concentrations similar to those found during smoking (0.5-5 muM), resulted in all CAI pyramidal neurones in a marked, phasic and tonic increase in the frequency and amplitude of spontaneous inhibitory currents. This effect was fully prevented by pre-incubation with the sodium channel blocker tetrodotoxin and was partially inhibited by the two nicotinic receptor antagonists methyllicaconitine (MLA) and dihydro-beta -erythroidine-(DH betaE). We conclude that, under conditions found during smoking, nicotine enhances inhibitory transmission, an effect exclusively mediated-through an enhancement of the firing rate of interneurones, without changes in spontaneous quantal release of GABA. NeuroReport 12:1351-1354. (C) 2001 Lippincott Williams & Wilkins.
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