Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 276, Issue 21, Pages 18337-18344Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M100495200
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Small phosphorylated metabolites from mycobacteria stimulate human gamma delta T lymphocytes. Although such phosphoantigens could prove useful in the composition of vaccines involving gamma delta T cell-mediated immunity, their very low abundance in natural sources limits such applications. Here, we describe the chemical production, purification, and bioactivity of a phosphorylated bromohydrin (BrHPP) analogue that mimics the biological properties of natural phosphoantigens, This compound can be obtained in gram amounts, is easy to detect, and is of high stability in aqueous solutions. Whereas unspecific binding of BrHPP to a wide panel of cell surface receptors is not detected even at micromolar concentrations, nanomolar concentrations specifically trigger effector responses of human gamma delta T lymphocytes, Thus, BrHPP is a novel molecule enabling potent immunostimulation of human gamma delta T lymphocytes.
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