Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 177, Issue 1-2, Pages 35-41Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0303-7207(01)00405-1
Keywords
GIP receptor; bone; bone mineral density; osteoporosis
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Funding
- NICHD NIH HHS [HD34149] Funding Source: Medline
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Glucose-dependent insulinotropic peptide (GIP) is a gut-derived hormone known to be important in modulating glucose-induced insulin secretion. In addition, GIP receptors are widely distributed and may have effects on multiple other tissues: fat cells, adrenal glands, endothelium and brain. We have demonstrated recently that GIP also has anabolic effects on bone-derived cells. We now demonstrate that GIP administration prevents the bone loss associated with ovariectomy. We propose that GIP plays a unique role in signaling the bone about nutrient availability, indicating the importance of the gut hormones in directing absorbed nutrients to the bone, and suggesting the concept of an 'entero-osseous axis'. Thus, GIP plays an integrative role helping coordinate efficient and targeted nutrient absorption and distribution. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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