Journal
BIOCHEMICAL JOURNAL
Volume 414, Issue -, Pages 189-194Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20081237
Keywords
ADP-ribosylation factor family (Arf family); amphipathic helix; clathrin-mediated endocytosis; coatamer protein (COP); membrane curvature sensing and generation; small G-protein
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Funding
- Swedish Research Council
- Medical Faculty of Umea University
- Magn. Bergvalls Foundation
- Trinity College Cambridge Internal Graduate Studentship
- MRC [MC_U105178795] Funding Source: UKRI
- Medical Research Council [MC_U105178795] Funding Source: researchfish
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Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf I and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.
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