Journal
BIOCHEMICAL GENETICS
Volume 52, Issue 9-10, Pages 430-442Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10528-014-9658-5
Keywords
IGF2BP2 rs4402960; CDKAL1 rs7756992; KCNJ11 rs5219; Genetic susceptibility; Morocco
Funding
- NEPAD/NABNet New Partnership for Africa's Development
- North Africa Biosciences Network
- Joint WHO/EMRO-COMSTECH RABGH
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Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
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