Synthesis of alkyl-substituted pyrroles by three-component coupling of carbonyl compound, amine and nitro-alkane/alkene on a solid surface of silica gel/alumina under microwave irradiation

Efficient synthesis of highly substituted alkylpyrroles and fused pyrroles has been achieved by a three-component coupling of (a) alpha,beta -unsaturated aldehyde/ketone, amine and nitroalkane and (b) alpha,beta -unsaturated nitroalkene, aldehyde/ketone and amine on the surface of silica gel and alumina without any solvent under microwave irradiation. (C) 2001 Elsevier Science Ltd. All rights reserved.