Journal
GENE
Volume 270, Issue 1-2, Pages 259-264Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-1119(01)00465-6
Keywords
Frost; proline-rich region; signal peptide
Categories
Ask authors/readers for more resources
Gene expression during recovery at 25 degreesC (rearing temperature) after cold shock (0 degreesC) was studied in Drosophila melanogaster using a subtraction technique. A novel gene (Frost, abbreviated as Fst) was considerably up-regulated during recovery after cold shock. In addition, a prolongation of cold shock was more effective for induction. In contrast to cold shock, Fst gene did not respond to heat shock. This gene is apparently the same as the unidentified gene, CG9434. Fst has high internal repeats not only in nucleotide but also in amino acid sequences. In addition, FST protein has a proline-rich region. The deduced amino acid sequence revealed a modular structure; i.e., a signal peptide in the N-terminal region followed by a long hydrophilic region. Therefore, this protein is likely to be directed into ER and secreted into extracellular space. (C) 2001 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available