Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans

The nervous system acts as a major regulator of the life span of Caenorhabditis elegans. Temperature and chemical stimuli from the environment are integrated with internal signals from the reproductive system to specify adult longevity. An insulin-like signaling cascade acts in neurons and coordinates control of senescence of the entire organism by regulating metabolism and a stress response mechanism. Caloric restriction extends life span, possibly by activation of the stress response program. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.