Journal
MOLECULAR MICROBIOLOGY
Volume 40, Issue 6, Pages 1323-1333Publisher
WILEY
DOI: 10.1046/j.1365-2958.2001.02475.x
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Funding
- NIGMS NIH HHS [R37 GM36278-17] Funding Source: Medline
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DegS (HhoB), a putative serine protease related to DegP/HtrA, regulates the basal and induced activity of the essential Escherichia coli sigma factor sigma (E), which is involved in the cellular response to extracytoplasmic stress. DegS promotes the destabilization of the sigma (E)-specific anti-sigma factor RseA, thereby releasing sigma (E) to direct gene expression. We demonstrate that degS is an essential E. coli gene and show that the essential function of DegS is to provide the cell with sigma (E) activity. We also show that the putative active site of DegS is periplasmic and that DegS requires its N-terminal transmembrane domain for its sigma (E)-related function.
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