Journal
NEUROSCIENCE LETTERS
Volume 305, Issue 1, Pages 5-8Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)01786-4
Keywords
oxidative stress; HIV-related dementia; Tat
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Funding
- NIDA NIH HHS [R01 DA013137, DA 09160, DA 13137, DA 11337, R01 DA013137-04] Funding Source: Medline
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Oxidative stress has been hypothesized to play a role in the pathogenesis of different neurodegenerative disorders, including HIV-related dementia. Tat, a nonstructural protein of HIV, is implicated in potentiation of neuronal apoptosis by mechanisms involving the disruption of calcium homeostasis and oxidative stress. The injection of Tar caused an increase of protein carbonyl formation in the rat striatum. Increased oxidative modification of proteins occurred early after Tat injection and preceded Tat-mediated astrogliosis. Immunostaining of brain sections demonstrated that an area of prominent protein carbonyl immunoreactivity surrounded an injection site in the striatum of Tat-injected rats. Intense protein carbonyl immunoreactivity was localized in cell bodies. Our study suggests that increased protein oxidation may be an important part of the mechanism of Tat neurotoxicity. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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