Journal
BIOCHEMICAL GENETICS
Volume 48, Issue 9-10, Pages 751-759Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10528-010-9357-9
Keywords
Cattle; CACNA2D1 gene; Carcass and meat quality traits; SNPs; Association analysis
Funding
- Earmarked fund for Modern Agroindustry Technology Research System [nycytx-38]
- New Variety of Transgenic Organism Great Breeding Program [2008ZX08007-002, 2009ZX08009-157B]
- Eleventh Five-Year National Science and Technology Support Project [2006BAD04A16, 2007BAD56B04]
- National 863 Program of China [2008AA10Z146]
- Public-welfare Profession Research Program [nyhyzx07-035-07]
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The objective of this study was to identify genetic polymorphisms of the CACNA2D1 gene and to analyze associations between SNPs and carcass and meat quality traits in cattle. Through PCR-RFLP and DNA sequencing methods, a new allelic variant corresponding to the A -> G mutation (aspartic to glycine amino acid replacement) of the bovine CACNA2D1 gene was detected. Two alleles and three genotypes (AA, AG, and GG) were defined. Genetic character indicated that the A526745G locus showed moderate polymorphism and was in Hardy-Weinberg equilibrium. Gene-specific SNP marker association analysis showed that the A526745G mutant was significantly associated with carcass weight, dressing percentage, meat percentage, and backfat thickness. The results add new evidence that CACNA2D1 is an important candidate gene for the selection of carcass and meat quality traits in the cattle industry.
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