Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 24, Issue 3, Pages 214-218Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02978260
Keywords
ginseng radix alba; ginseng radix palva; hexokinase; glucose-6-phosphatase; PPAR-gamma
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The mechanisms responsible for the antidiabetic activity of both the white ginseng radix (Ginseng Radix Alba, GRA) and the rootlet (Ginseng Radix Palva, GRP) were investigated. After a four week oral administration, the fasting blood glucose levels in the GRA- and GRP-treated groups were lower when compared to the control group. To elucidate the hypoglycemic mechanism(s) of the ginseng radices, glucose absorption from the small intestine, hepatic hexokinase and glucose-6-phosphatase activities, in addition to PPAR-gamma expression in adipose tissue were Examined. The results strongly suggest that GRA can improve hyperglycemia in KKAy mice, possibly by blocking intestinal glucose absorption and inhibiting hepatic glucose-6-phosphatase, and GRP through the upregulation of adipocytic PPAR-gamma protein expression as well as inhibiting intestinal glucose absorption.
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