Journal
TRENDS IN IMMUNOLOGY
Volume 22, Issue 6, Pages 337-342Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(01)01930-5
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Funding
- NHLBI NIH HHS [HL57345] Funding Source: Medline
- NIGMS NIH HHS [GM32373] Funding Source: Medline
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Siglecs are members of the Ig superfamily that bind to sialic acid (Sia) and are mainly expressed by cells of the hematopoietic system. Until three years ago, only four Siglecs were known, namely sialoadhesin. CD22, myelin-associated glycoprotein and CD33. Since then, a further six human CD33-related Siglecs with features of inhibitory receptors have been identified and shown to be expressed by discrete subsets of leukocytes. Recognition of Sia by these Siglecs could play a role in the regulation of the innate immune system.
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