Journal
CELL DEATH AND DIFFERENTIATION
Volume 8, Issue 6, Pages 640-648Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4400855
Keywords
ARC; caspase-2; PC12 cells; serum withdrawal; aggregation; apoptosis
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The role of ARC (Apoptosis Repressor with Caspase Recruitment Domain) in PC12 cell serum withdrawal driven apoptosis was studied. A progressive and massive increase in ARC protein occurs during serum withdrawal that correlates with declining survival and processing of caspase-2, previously shown to associate with ARC.(1) This accumulation of ARC occurs in a transcriptional and translational independent manner. Additionally, ARC is localized exclusively in the nucleus of PC12 cells. Furthermore, transfection of PC12 cells with hARC-Flag promotes death and fails to protect the cells from apoptosis by serum withdrawal. Therefore, ARC functions in a pro-apoptotic manner in PC12 cell serum withdrawal induced apoptosis.
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