Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 12, Pages 5677-5683Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.12.5677-5683.2001
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The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viral mRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells, Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen the potential role of E1B-55K as the driving force for adenoviral late mRNA export.
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