Journal
BIOCHEMICAL ENGINEERING JOURNAL
Volume 56, Issue 3, Pages 150-157Publisher
ELSEVIER
DOI: 10.1016/j.bej.2011.06.001
Keywords
Succinic acid; Expanded-bed adsorption; Bioreactors; Process integration; Product inhibition; Bioconversion
Funding
- State Major Basic Research Development Program of China [2007CB714305]
- Chinese Academy of Sciences [KSCX2-EW-G-2-2]
- National High Technology Research and Development Program of China [2011AA02A203]
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An integrated fermentation process for the production of succinic acid by Actinobacillus succinogenes at high titer, yield and productivity was developed by applying in situ product removal (ISPR) strategy. The ISPR process was conducted by a coupled expanded-bed adsorption (EBA) system. The novel approach during the product inhibitory period of microbial fermentation enhanced the cell growth of A. succinogenes from 48 h to 126 h, and significantly increased succinic acid production up to the final titer of 145.2 g l(-1) with an average yield of 0.52 g g(-1), and productivity of 1.3 g l(-1) h(-1). The maximum yield and productivity reached 0.76 g g(-1) and 2.58 gl(-1) h(-1), respectively after the first ISPR operation cycle. ISPR process with EBA leads to the production of succinct acid via fermentation economically feasible. (C) 2011 Elsevier B.V. All rights reserved.
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