Journal
JOURNAL OF CLINICAL VIROLOGY
Volume 21, Issue 3, Pages 223-228Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1386-6532(00)00165-7
Keywords
ganciclovir; dynamics; cell culture; polymerase
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The molecular basis for cytomegalovirus drug resistance against currently used antivirals comprises two genetic loci. In the case of ganciclovir, mutations in both the UL97 protein kinase and UL64 DNA polymerase can lead to resistance, whereas for cidofovir and foscarnet only mutations in UL54 give rise to resistance. Clinically, resistance strains of cytomegalovirus appear after prolonged periods of antiviral therapy especially when treatment has been interrupted or is at sub-optimal doses. Knowledge of the replication dynamics of cytomegalovirus in vivo can be used to predict the virologic course of patients who develop resistance virus. Using such models, a good agreement between experimentally determined viral load and resistance patterns is observed. (C) 2001 Elsevier Science B.V. All rights reserved.
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