Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 2, Issue 6, Pages 409-421Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35073039
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How can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development. Here we try to formulate a broad framework for the types of molecular mechanism used by the Polycomb and trithorax proteins.
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