Journal
PARASITE
Volume 8, Issue 2, Pages S188-S190Publisher
EDP SCIENCES S A
DOI: 10.1051/parasite/200108s2188
Keywords
albendazole; bioavailability; Trichinella; cyclodextrins
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The bioavailability and anthelmintic activity of albendazole cyclodextrin complexes (ABZ-CDC) compared to albendazole suspensions in carboxymethylcellulose (ABZ-CMC) was assessed in a mouse model for Trichinella infections. Swiss CD-I mice experimentally infected with T.spiralis were treated with both formulations against enteral (adult worms) and parenteral (migrating and encysted larvae). Oral bioavailability was assessed in age matched mice treated with 50 mg/kg of both formulations. The anthelmintic effects and plasma concentration of the active metabolite albendozole-sulphoxide (ABZSO) enantiomer (-) were significantly increased following administration of ABZ-CDC in relation to ABZ-CDC.
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