Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 26, Issue 6, Pages 376-384Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(01)01827-8
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The posttranscriptional modification of messenger RNA precursors (pre-mRNAs) by base deamination can profoundly alter the physiological function of the encoded proteins. The recent identification of tRNA-specific adenosine deaminases (ADATs) has led to the suggestion that these enzymes, as well as the cytidine and adenosine deaminases acting on pre-mRNAs (CDARs and ADARs), belong to a superfamily of RNA-dependent deaminases. This superfamily might have evolved from an ancient cytidine deaminase, This article reviews the reactions catalysed by these enzymes and discusses their evolutionary relationships.
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