Journal
BIOCHEMICAL ENGINEERING JOURNAL
Volume 44, Issue 2-3, Pages 232-239Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bej.2008.12.013
Keywords
Bioseparations; Membrane; Mass-transfer; Affinity; Dopamine; Molecularly imprinted polymer
Funding
- Department of Science and Technology [SR/S1/1C-18/2006]
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Induced-fit responsive dopamine (DA) imprinted polymer, poly (melamine-co-chloranil). was used as a suitable coating material for the modification of a hanging mercury drop electrode. The zwitterionic conformation of the imprinted polymer responded differential pulse, cathodic stripping voltammetric current, without any false-positive or false-negative contributions of non-specific sorptions, in aqueous environment of complex matrices. The limit of detection (3 sigma) of dopamine was found to be as low as 0.148 ng mL(-1). by the proposed sensor that could be considered a sensitive marker of dopamine depletion in Parkinson's disease (PD). (C) 2008 Elsevier B.V. All rights reserved.
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