Journal
NATURE STRUCTURAL BIOLOGY
Volume 8, Issue 6, Pages 476-478Publisher
NATURE AMERICA INC
DOI: 10.1038/88519
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Funding
- NHLBI NIH HHS [R37 HL063762] Funding Source: Medline
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The LDL receptor plays a central role in the control of plasma cholesterol levels and the prevention of coronary artery disease. Recent studies now shed light on the structural organization of several independently folded modules and domains from which the receptor is assembled, providing substantial insights into the mechanics of receptor function and the consequences of disease causing mutations.
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