4.6 Article

Dynamics of alternative polyadenylation in human preimplantation embryos

Journal

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2018.09.027

Keywords

Alternative polyadenylation (APA); 3 ' untranslated region (3 '-UTR); lncRNA; Preimplantation embryo development; RNA-seq

Funding

  1. Ministry of Science and Technology, Taiwan [MOST 104-2628-E-010-001-MY3, 105-2320-B-002-057-MY3, 07-2221-E-010-017-MY2]

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Alternative polyadenylation (APA) affects the length of the 3' untranslated region (3'-UTR) and the regulation of microRNAs. Previous studies have shown that cancer cells tend to have shorter 3'-UTRs than normal cells. A plausible explanation for this is that it enables cancer cells to escape the regulation of microRNAs. Here, we extend this concept to an opposing context: changes in 3'-UTR length in the development of the human preimplantation embryo. Unlike cancer cells, during early development 3'-UTRs tended to become longer, and gene expression was negatively correlated with 3'-UTR length. Moreover, our functional enrichment results showed that length changes are part of the development mechanism. We also investigated the analogy of 3'-UTR length variation with respect to lncRNAs and found that, similarly, lncRNA length tended to increase during embryo development. (C) 2018 Elsevier Inc. All rights reserved.

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