Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 503, Issue 3, Pages 1689-1695Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2018.07.100
Keywords
Ferroptosis; Erastin; PBMCs; Immunity; Lipid peroxidation
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Funding
- US National Institutes of Health [R01GM115366, R01CA160417, R01CA211070]
- Natural Science Foundation of Guangdong Province [2016A030308011, 2017A030313558]
- American Cancer Society [RSG-16-014-01-CDD]
- National Natural Science Foundation of China [31671435, 81602380, 81401205, 81772508]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2017)
- Lin He's Academician Workstation of New Medicine and Clinical Translation
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Peripheral blood mononuclear cells (PBMCs) contain multipotent progenitor cell populations and possess the potential to differentiate into various types of immune cells under both physiological and pathological conditions. Ferroptosis is a type of oxidative stress-associated cell death that is mainly mediated by lipid peroxidation. However, the function of ferroptosis in cell differentiation remains unknown. Here, we showed that the ferroptosis inducer erastin did not cause cell death in human PBMCs. In contrast, erastin-induced lipid peroxidation promoted human PBMC proliferation and differentiation into B cells and natural killer cells through inhibition of bone morphogenetic protein family expression. These findings uncover a new immune modulation function of erastin in promoting PBMC proliferation and differentiation. (C) 2018 Elsevier Inc. All rights reserved.
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