Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 11, Issue 3, Pages 348-353Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00214-1
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Comparison of protein structures can reveal distant evolutionary relationships that would not be detected by sequence information alone. This helps to infer functional properties. In recent years, many methods for pairwise protein structure alignment have been proposed and are now available on the World Wide Web. Although these methods have made it possible to compare all available protein structures, they also highlight the remaining difficulties in defining a reliable score for protein structure similarities.
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