Journal
NEURON
Volume 30, Issue 3, Pages 699-706Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(01)00320-8
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM 54339] Funding Source: Medline
Ask authors/readers for more resources
The clock gene double-time (dbt) encodes an ortholog of casein kinase le that promotes phosphorylation and turnover of the PERIOD protein. Whereas the period (per), timeless (tim), and dClock (dClk) genes of Drosophila each contribute cycling mRNA and protein to a circadian clock, dbt RNA and DBT protein are constitutively expressed. Robust circadian changes in DBT subcellular localization are nevertheless observed in clock-containing cells of the fly head. These localization rhythms accompany formation of protein complexes that include PER, TIM, and DBT, and reflect periodic redistribution between the nucleus and the cytoplasm. Nuclear phosphorylation of PER is strongly enhanced when TIM is removed from PER/TIM/DBT complexes. The varying associations of PER, DBT and TIM appear to determine the onset and duration of nuclear PER function within the Drosophila clock.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available