Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro

The 50% ethanol extract of the whole plant of Solanum nigrum was tested in vitro for its cytoprotection against gentamicin-induced toxicity on Vero cells. Cytotoxicity was significantly inhibited as assessed by the Trypan blue exclusion assay and mitochondrial dehydrogenase activity (MTT) assay. The test extract also exhibited significant hydroxyl radical scavenging potential, thus suggesting its probable mechanism of cytoprotection. (C) 2001 Elsevier Science B.V. All rights reserved.