4.6 Article

Therapeutic potential of flurbiprofen against obesity in mice

Journal

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.04.159

Keywords

STAT3; Nonsteroidal anti-inflammatory drug (NSAID); Flurbiprofen; Leptin

Funding

  1. Institute of Laboratory Animal Science (Hiroshima University)
  2. Ministry of Education, Culture, Sports, Science, and Technology, Japan
  3. Takeda Science Foundation
  4. Tokyo Biochemical Research Foundation
  5. Suzuken Memorial Foundation
  6. Nakajima Foundation

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Obesity is associated with several diseases including diabetes, nonalcoholic steatohepatitis (NASH), hypertension, cardiovascular disease, and cancer. Therefore, anti-obesity drugs have the potential to prevent these diseases. In the present study, we demonstrated that flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), exhibited therapeutic potency against obesity. Mice were fed a high-fat diet (HFD) for 6 months, followed by a normal-chow diet (NCD). The flurbiprofen treatment simultaneously administered. Although body weight was significantly decreased in flurbiprofen-treated mice, growth was not affected. Flurbiprofen also reduced the HFD-induced accumulation of visceral fat. Leptin resistance, which is characterized by insensitivity to the anti-obesity hormone leptin, is known to be involved in the development of obesity. We found that one of the possible mechanisms underlying the anti-obesity effects of flurbiprofen may have been mediated through the attenuation of leptin resistance, because the high circulating levels of leptin in HFD-fed mice were decreased in flurbiprofen-treated mice. Therefore, flurbiprofen may exhibit therapeutic potential against obesity by reducing leptin resistance. (C) 2014 Elsevier Inc. All rights reserved.

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