Journal
CONTACT DERMATITIS
Volume 44, Issue 6, Pages 344-346Publisher
WILEY
DOI: 10.1034/j.1600-0536.2001.044006344.x
Keywords
allergic contact dermatitis; fragrance; jasmine absolute; geranium oil bourbon; 1-citronellol; spearmint oil; 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran; omega-6-hexadecenlactone; dimethyltetrahydrobenzaldehyde; alpha-amylcinnamaldehyde
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The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 178 patients were evaluated in 8 centers worldwide with a fragrance mix (FM) and 20 other fragrance materials. Reaction to the fragrance mixture (FM) occurred in 78.7% of the subjects. Substances reacting at a rate of 2% or higher included jasmine absolute, geranium oil bourbon, 1-citronellol, spearmint oil, 1,3,4,6.7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma -2-ben omega-6-hexadecenlactone, dimethyltetrahydrobenzaldehyde (isomer mixture), and alpha -amylcinnamaldehyde. These chemicals should be furthur evaluated to corroborate their allergenicity. We are constantly looking for new fragrance allergens to extend the diagnostic capability of the fragrance mix (FM).
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