Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 13, Issue 3, Pages 291-298Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(00)00218-1
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Dendritic cells are responsible for directing different types of T cell responses, from thymic negative selection to the generation of effector and memory cells and the induction of peripheral tolerance. Recent studies indicate that the dendritic cell lineage, the extent of recruitment into inflamed tissues and migration to lymph nodes, the nature of maturation stimuli and the kinetics of activation have a quantitative and qualitative impact on T cell stimulation, thus exerting an instructive control on T cell responses.
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