Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 2, Issue 6, Pages 433-443Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35073057
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Funding
- Cancer Research UK [11722] Funding Source: Medline
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Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.
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