Journal
CELL RESEARCH
Volume 11, Issue 2, Pages 89-94Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cr.7290072
Keywords
transforming growth factor beta; apoptosis; p38; hepatocyte; signal transduction
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We reported in this manuscript that TGF-beta1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-beta1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-beta1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-beta1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-beta1-mediated gene expression and apoptosis.
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