Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 445, Issue 2, Pages 524-533Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.02.054
Keywords
ER stress; Autophagy; IRE1 alpha; CHOP
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Funding
- Grants-in-Aid for Scientific Research [23590932] Funding Source: KAKEN
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To explore the relationship between UPR and autophagy in intestinal epithelial cells, we investigated whether autophagy was induced by endoplasmic reticulum (ER) stress in colon cancer cell lines. We demonstrated that autophagy was induced by ER stress in HT29, SW480, and Caco-2 cells. In these cells, inositol-requiring enzyme1 alpha (IRE1 alpha) and C/EBP homologous protein (CHOP) were involved in the ER stress-autophagy pathway, and CHOP was a regulator of IRE1 alpha, protein expression. Our findings suggest that CHOP promotes IRE1 alpha and autophagy especially in ER stress conditions. This study will provide important insights into the disclosure of the ER stress-autophagy pathway. (C) 2014 Elsevier Inc. All rights reserved.
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