Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 33, Issue 6, Pages 1065-1089Publisher
ELSEVIER SCI LTD
DOI: 10.1006/jmcc.2001.1378
Keywords
cytochrome; fatty acid oxidation; reactive oxygen species; apoptosis; preconditioning; aging; ischemia; reperfusion
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Funding
- NIA NIH HHS [1K04AG00676, 1RO1AG12447] Funding Source: Medline
- SAMHSA HHS [1POAG15885] Funding Source: Medline
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Mitochondria contribute to cardiac dysfunction and Myocyte injury via a loss of metabolic capacity and by the production and release of toxic products. This article discusses aspects of mitochondrial structure and metabolism that are pertinent to the role of mitochondria in cardiac disease. Generalized mechanisms of mitochondrial-derived myocyte injury are also discussed, as are the strengths and weaknesses of experimental models used to study the contribution of mitochondria to cardiac injury. Finally, the involvement of mitochondria in the pathogenesis of specific cardiac disease states (ischemia, reperfusion, aging, ischemic preconditioning, and cardiomyopathy) is addressed. (C) 2001 Academic Press.
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