Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 450, Issue 1, Pages 692-696Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.06.033
Keywords
Histone methylation; H4K20me1; Androgen receptor; Transcription activation; SET8
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Funding
- National Basic Research Program of China (973 Program) [2012CB518302]
- National Natural Science Foundation of China [91019024]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01040407]
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Histone methylation status in different lysine residues has an important role in transcription regulation. The effect of H4K20 monomethylation (H4K20me1) on androgen receptor (AR)-mediated gene transcription remains unclear. Here we show that AR agonist stimulates the enrichment of H4K20me1 and SET8 at the promoter of AR target gene PSA in an AR dependent manner. Furthermore, SET8 is crucial for the transcription activation of PSA. Co-immunoprecipitation analyses demonstrate that SET8 interacts with AR. Therefore, we conclude that SET8 is involved in AR-mediated transcription activation, possibly through its interaction with AR and H4K20me1 modification. (C) 2014 Elsevier Inc. All rights reserved.
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