Journal
DEVELOPMENTAL DYNAMICS
Volume 221, Issue 2, Pages 231-237Publisher
WILEY-LISS
DOI: 10.1002/dvdy.1132
Keywords
cadherin; zebrafish; Danio rerio; neurogenesis; midbrain; hindbrain; wnt1; pax2.1; cyclops
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Funding
- NEI NIH HHS [EY11365, EY06892, EY04318] Funding Source: Medline
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Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB), Developmental. regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHD was dependent on normal development of this structure. (C) 2001 Wiley-Liss, Inc.
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