Journal
NMR IN BIOMEDICINE
Volume 14, Issue 4, Pages 247-259Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/nbm.697
Keywords
lineshape fitting; frequency domain; quantitation; in vivo; in vitro; MRS
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There has been a vast increase in applications of magnetic resonance spectroscopy (MRS) in biomedical research during the last few years, This is not surprising since MRS provides both in vivo and in vitro a non-invasive tool for various biochemical and biomedical studies. There are also expectations that clinical MRS will have an important role as a diagnostic: tool. An essential prerequisite for the future success of MRS for applicability in biomedical sciences will be accurate and biochemically relevant data analysis (at as high a level of automation as possible). This review briefly describes principles of the methodology available for advanced quantitative data analysis in the frequency domain. Various biomedical applications are discussed in order to illustrate the practical aspects of the analyses and to show the applicability and power of biochemical prior knowledge-based lineshape fitting analysis. Copyright (C) 2001 John Wiley & Sons, Ltd.
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