Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 12, Issue 3, Pages 215-223Publisher
ACADEMIC PRESS LTD
DOI: 10.1006/scdb.2000.0247
Keywords
cell wall; drug resistance; efflux; mycolic acid; outer membrane
Categories
Funding
- NIAID NIH HHS [AI-09644] Funding Source: Medline
Ask authors/readers for more resources
Bacteria, being unicellular, are constantly exposed to toxic compounds in their environment. Gram-negative bacteria and mycobacteria are unusually successful in surviving in the presence of toxic compounds because they combine two mechanisms of resistance. They produce effective permeability barriers, comprising the outer membrane and the mycolate-containing cell wall, on the cell surface. Further, they actively pump out drug molecules that trickle through the barrier, often utilizing multidrug efflux pumps. In Gram-negative bacteria, multidrug pumps of exceptionally wide specificity frequently interact with outer membrane channels and accessory proteins, forming multisubunit complexes that extrude drug molecules directly into the medium, bypassing the outer membrane barrier.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available