Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 451, Issue 4, Pages 503-509Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.07.132
Keywords
Amyotrophic lateral sclerosis; Differentiation; Umbilical cord blood mono-nuclear cell; Pluripotency; Transcription factor
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Funding
- Russian Science Foundation [13-04-97156, 14-15-00847]
- Program of Competitive Growth of Kazan Federal University
- Asklepios-Med (Hungary)
- Russian Science Foundation [14-15-00847] Funding Source: Russian Science Foundation
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Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis. (C) 2014 Elsevier Inc. All rights reserved.
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