Journal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume 37, Issue 7, Pages 1891-1900Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0735-1097(01)01236-0
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OBJECTIVES The goal of this study was to determine the effects of exercise training (ET) on functional capacity and quality of life (QOL) in patients who received percutaneous transluminal coronary angioplasty (PTCA) or coronary stenting (CS), the effects on the restenosis rate and the outcome. BACKGROUND It is unknown whether ET induces beneficial effects after coronary angioplasty. METHODS We studied 118 consecutive patients with coronary artery disease (mean age 57 +/- 10 years) who underwent PTCA or CS on one (69%) or two (31%) native epicardial coronary arteries. Patients were randomized into two matched groups. Group T (n = 59) was exercised three times a week for six months at 60% of peak (V) over dot O-2. Group C (n = 59) was the control group. RESULTS Only trained patients had significant improvements in peak (V) over dot O-2 (26%, p < 0.001) and quality of life (26.8%, p = 0.001 vs. C). The angiographic restenosis rate was unaffected by ET (T: 29%; C: 33%, P = NS) and was not significantly different after PTCA or CS. However, residual diameter stenosis was lower in trained patients (-29.7%, p = 0.045). In patients with angiographic restenosis, thallium uptake improved only in group T (19%; p < 0.001). During the follow-up (33 +/- 7 months) trained patients had a significantly lower event rate than controls (11.9 vs. 32.2%, RR: 0.71, 95% confidence interval [CI]: 0.60 to 0.91, p = 0.008) and a lower rate of hospital readmission (18.6 vs. 46%, RR: 0.69, 95% CI: 0.55 to 0.93, p < 0.001). CONCLUSIONS Moderate ET improves functional capacity and QOL after PTCA or CS. During the follow-up, trained patients had fewer events and a lower hospital readmission rate than controls, despite an unchanged restenosis rate. (J Am Coll Cardiol 2001;37:1891-900) (C) 2001 by the American College of Cardiology.
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